I know this is a niche situation, but for power users here that have responsibilities in multiple domains, when you switch location documents to another Domino domain and then go back, you lose the tabs previously opened before switching.  So, have Notes track open tabs for each domain as part of bookmarks or desktop6.ndk. Thus, when you go from your production domain to your client's or development domain, you can switch back and have all your tabs visible when you return.

 

Otherwise, it can be a real productivity impediment to keep switching if you need to help clients and then come back and try to recall all of the work you were involved with previously--similar to the idea of saving workspace state preference setting, but expanding it to other location documents.  Note: this implies that switching location documents also switches ID files (which is located in the location document's Advanced->Basics->User ID to switch to, field)